No views 25 May 2022 The second and third generation smallpox vaccinations, both live virus vaccines based on the vaccinia virus, are effective against monkeypox. Vaccinia is another orthopoxvirus that protects against smallpox and monkeypox, but it can have major adverse effects in some people, particularly those with weakened immune systems. Because of the risks, mass immunization is not recommended. Rather than mass immunization, the ideal technique is to identify contacts and vaccinate them.
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