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The Melbourne Renegades have won the toss and will bat first in their bid to arrest a three-match losing skid against BBL ladder leaders the Perth Scorchers.
Renegades veteran Shaun Marsh will miss the clash against his former team, rested after playing two matches in the space of three days on his return from injury.
Marsh has been replaced by Mackenzie Harvey, who slots into the middle order.
The Scorchers have lost left-arm spinner Ashton Agar after his call-up for Australia's third Test against South Africa.
But former Test batsman Cameron Bancroft returns for his first match of the season.
The two sides enter the clash with contrasting fortunes.
Perth (4-1) are flying on the back of three straight wins, while a trio of consecutive losses have undone the positive start the Renegades (3-3) made to the tournament.
Those defeats have come off the back of limp batting displays, with the Renegades posting scores of 114, 115 and 7-124 in their most recent matches.
West Indian import Akeal Hosein backed the high-powered batting line-up - led by Martin Guptill, Nic Maddinson and Aaron Finch - to bounce back against the Scorchers with a simple approach.
"It's mainly around sticking to what we know best," Hosein said.
"We have some top quality batsmen, guys that are in the top five most runs of all-time in BBL as well, so it's just about sticking together and being positive.
"We know we can turn it around and get the positive results we need."
Renegades veteran Aaron Finch has 2988 career runs in the BBL and is chasing a slice of history as he seeks to become the second player behind Chris Lynn to reach 3000.
MELBOURNE RENEGADES: Martin Guptill, Nic Maddinson (capt), Peter Handscomb, Aaron Finch, Jonathan Wells, Mackenzie Harvey, Akeal Hosein, Will Sutherland, Tom Rogers, Kane Richardson, Mujeeb Ur Rahman.
PERTH SCORCHERS: Adam Lyth, Faf du Plessis, Cameron Bancroft, Josh Inglis, Ashton Turner (capt), Aaron Hardie, Nick Hobson, Jhye Richardson, Andrew Tye, Jason Behrendorff, Peter Hatzoglou.