Brisbane Heat captain Jimmy Peirson has won the toss and elected to bat first against the Melbourne Renegades in the BBL clash in Geelong.
The second-placed Renegades are looking to continue their hot form after winning their opening two matches, including a 22-run victory over the Heat in Cairns last week.
Brisbane, who have only played once, have since been bolstered by the return of paceman Michael Neser and batsman Matt Renshaw.
Neser missed the opening match while on Test duty for Australia against South Africa, while Renshaw sat out to be present at the birth of his first child.
Renshaw rejoined the Heat during the winter after being released by the Adelaide Strikers.
He and fellow batsman Max Bryant will play their 50th BBL games on Wednesday night.
The Renegades are unchanged from the side that beat Sydney Thunder by four wickets on Sunday.
Renegades captain Nic Maddinson top-scored with 87 last time against the Heat and is the competition's second-highest run-scorer with an average of 63.
Former Australia international Shaun Marsh has arrived in Melbourne but is still recovering from a calf injury and remains unavailable for the Renegades.
Melbourne Renegades: Sam Harper, Nic Maddinson (capt), Jake Fraser-McGurk, Aaron Finch, Jon Wells, Andre Russell, Akeal Hosein, Will Sutherland, Tom Rogers, Kane Richardson, Mujeeb Ur Rahman.
Brisbane Heat: Max Bryant, Colin Munro, Matt Renshaw, Sam Billings, Jimmy Peirson (capt), Ross Whiteley, James Bazley, Michael Neser, Mark Steketee, Matt Kuhnemann, Mitch Swepson.