SMC Laboratories Reveals Innovative STAM™-HCC/IO+ Mouse for Identifying and Developing Novel Therapeutic Drugs for Liver Cancer, Blazing a Trail in the Immuno-Oncology Field

TOKYO, Feb. 7, 2024 /PRNewswire/ -- SMC Laboratories, Inc. ("SMC Laboratories"), a non-clinical contract research organization (CRO) that provides consulting and contract services for pharmacology studies utilizing technology and know-how related to Metabolic dysfunction associated steatohepatitis (MASH), inflammation, fibrosis, metabolism, and immunity, recently launched their innovative STAM™-HCC/IO⁺ mouse – a first in the field of tumor immuno-oncology – to develop new liver cancer therapeutic drugs. The company specializes in liver-related services and has evaluated test substances in over 15 MOA categories as well as over 270 target molecules using the STAM™ mouse.

The STAM™-HCC/IO⁺ mouse is a model that allows stable evaluation of the growth of multiple target lesions originating from the liver over a certain period. Furthermore, it can be used for testing molecular target drugs and immune checkpoint inhibitors, and for other therapeutic targets while performing stable drug efficacy evaluations. The market for immunotherapy drugs based on immuno-oncology is increasing every year, and a variety of tumor immunotherapy drugs such as stromal modifying agents, adaptive cell therapy, tumor targeting antibodies, immunogenic cell death inducers, metabolic inhibitors, and immune effector cell modulators are being developed. As the prevalence of liver cancer increases, it is anticipated that SMC Laboratories' STAM™-HCC/IO⁺ mouse will greatly contribute to the development of therapeutic drugs for liver cancer in the future.

Liver cancer is the fourth most common type of cancer in the world (Huang DQ et al, Nature Reviews Gastroenterology & Hepatology, 18, 223-238, 2021). The proportion of MASH/NASH patterns with non-virus-related cancer is also increasing annually. In addition to molecular target drugs such as lenvatinib and sorafenib, immune checkpoint inhibitors (ICIs) such as atezolizumab + bevacizumab, nivolumab, and pembrolizumab have also recently been used in clinical practice as therapeutic drugs for liver cancer. Therefore, future developments are highly anticipated. (Chen C et al, frontiers in Immunology, 14, 1133308, 2023). However, the response rate of ICIs for liver cancer is still low, ranging from 0-14%, compared to other types of cancer (e.g., melanoma response rate; 35-70%), thus there is a great demand for the development of new treatments (Tan S et al, JACC: CardioOncology, 4, 579-597, 2022, Valero C et al, JAMA Oncology, 7, 1245-1246, 2021). Due to this information, along with recent revelations in the field of tumor immunology, SMC Laboratories has successfully leveraged the characteristics of its STAM™-HCC/IO⁺ mouse, which enables the provision of non-clinical pharmacological services for new liver cancer therapeutics, including ICIs.

Through the company's research, it has become apparent that the STAM™-HCC/IO⁺ mouse model has a high tumor mutation burden with the following features:

• Tumor-infiltrating T cells (TILs), CD8+ cytotoxic T cells (CTLs)
• ICI monotherapy and/or combination therapy
• Tumor microenvironmental components
• Changes from baseline [sum of the longest diameters of target lesions]

These characteristics are extremely useful in evaluating treatments based on tumor immune control in non-clinical studies, and the STAM™-HCC/IO⁺ mouse, which has all of these features, is currently the most suitable non-clinical liver cancer mouse model for tumor immunology research (Shalapour S et al, Nature, 551, 340-345, 2017, Dow M et al, PNAS, 115: E9879-E9888, 2018). It is possible to evaluate the anti-tumor effects of ICIs not only in monotherapy studies but also in combination studies. This can be accomplished by using anti-PD-L1 antibody as a control, and directly comparing results.

About SMC Laboratories

SMC Laboratories, Inc. is a CRO, with a focus on conducting the non-clinical research necessary for the drug development process. As a global consulting company that designs studies according to customer requests, it supports cutting-edge non-clinical pharmacological studies. The company owns a variety of mouse models for inflammation and fibrosis in various organs, centered on the innovative STAM™ mouse' animal model of liver cancer derived from MASLD (metabolic dysfunction-associated steatotic liver disease). This patented mouse model was developed by SMC Laboratories as a worldwide-first model based on MASLD. We offer non-clinical pharmacological studies using the model mouse. Please check the company's website for further details.

For further inquiries, please visit SMC Laboratories Inc.,SMC Laboratories (smccro-lab.com)  or contact Taishi Hashiguchi, Ph.D. by [email protected] or [email protected].

Media Contact: Miyu Ueno [email protected]