Imugene’s Preclinical New Mimotope Cancer Vaccine Research Published in Prestigious Journal

  • May 29, 2020 AEST
  • Team Kalkine
Imugene’s Preclinical New Mimotope Cancer Vaccine Research Published in Prestigious Journal

Summary

  • Imugene's preclinical research associated with mimotope vaccines targeting immune checkpoint inhibitors published in 'Frontiers in Immunology' journal.
  • Research discovered that mimotope peptides when included in Imugene's exclusive immunotherapeutic vaccine delivery platform, produce antibodies that particularly bind to immune cells expressing the PD1 biomarker.
  • Imugene seems to be advancing well on its vision to help transform cancer treatment, strongly backed by peer-reviewed research and mounting body of clinical evidence.

Clinical stage immuno-oncology player, Imugene Limited's (ASX:IMU) preclinical research associated with its mimotope vaccines targeting immune checkpoint inhibitors (ICI) has been approved and published in the eminent journal 'Frontiers in Immunology' with the title 'New Strategy Toward B Cell-Based Immunotherapy by Active Immunization With Mimotopes of Immune Checkpoint Inhibitors'.

The publication is a detailed research of the course of action of active immunisation aimed at immune checkpoint regulator PD1. The ground-breaking research from Medical University of Vienna was carried out under the leadership of Imugene's Scientific Advisory Board (SAB) member, Professor Dr Ursula Wiedermann, along with Dr Joshua Tobias as lead author.

Key Outcomes of Preclinical Research

The research published in the journal has discovered that mimotope peptides when included in the Company's exclusive immunotherapeutic vaccine delivery platform, produce antibodies that particularly bind to immune cells expressing the PD1 biomarker.

These naturally generated antibodies inhibit a protective mechanism on cancer cells, enabling immune system to kill those cancer cells, similar to breast cancer animal models.

Imugene notified that this is the first journal report of treating cancer by teaching and encouraging the body to produce its own antibodies targeting PD1 expressing cells. Consequently, the approach signifies a paradigm shift in oncology segment.

On this new development, Imugene's MD & CEO, Leslie Chong commented:

PD1-Vaxx to Enter Phase 1 trial in 2020

The research outcomes validate and support the B cell "epitope" embodied in PD1-Vaxx, targeted to enter a Phase 1 trial in 2020.

Imugene's PD-1 targeting cancer immunotherapy, PD1-Vaxx is targeted to treat patients with small cell lung cancer and produce an anti-cancer effect similar to other immune checkpoint inhibitors and monoclonal antibodies (such as Opdivo® and Keytruda® that are transforming treatment of varied cancer forms) by interfering with PD-1/PD-L1 interaction and binding.

Recently, Imugene's Vice President of Clinical Research, Dr Anthony Good presented the clinical plan for its PD1-Vaxx at American Association for Cancer Research Virtual Annual Meeting 2020.

The primary objective of this B-cell cancer immunotherapy's phase 1 trial is to evaluate safety profile and an optimal biological dose as monotherapy and in combination with immune checkpoint inhibitors. Besides, the study also aims at measuring tolerability, immune response and efficacy.

Imugene seems to be well positioned to progress with PD1-Vaxx Phase 1 trial in 2020, backed by incredible workflow from its scientists and a highly skilled management team. The Company's robust balance sheet and capital position further strengthens the prospects for the same.

Also Read! Imugene Announced Completion of GMP manufacturing and Toxicology Studies for PD1-Vaxx

IMU closed the trading session at $0.034 on 29th May 2020.

 

There is no investor left unperturbed with the ongoing trade conflicts between US-China and the devastating bushfire in Australia.

Are you wondering if the year 2020 might not have taken the right start? Dividend stocks could be the answer to that question.

As interest rates in Australia are already at record low levels, find out which dividend stocks are viewed as the most attractive investment opportunity in the current scenario in our report.

CLICK HERE FOR YOUR FREE REPORT!

 


Disclaimer
The website https://kalkinemedia.com/au is a service of Kalkine Media Pty. Ltd. A.C.N. 629 651 672. The article has been prepared for informational purposes only and is not intended to be used as a complete source of information on any particular company. The above article is sponsored but NOT a solicitation or recommendation to buy, sell or hold the stock of the company (or companies) or engage in any investment activity under discussion. We are neither licensed nor qualified to provide investment advice through this platform. All pictures are copyright to their respective owner(s). Kalkinemedia.com does not claim ownership of any of the pictures displayed on this website unless stated otherwise. Some of the images used on this website are taken from the web and are believed to be in public domain. We have used reasonable efforts to accredit the source (public domain/CC0 status) to where it was found and indicated it below the image.

 

   
x
We use cookies to ensure that we give you the best experience on our website. If you continue to use this site we will assume that you are happy with it. OK