Nurix drops after new early-stage trial data for lead asset

June 13, 2025 04:46 AM AEST | By EODHD
 Nurix drops after new early-stage trial data for lead asset
Image source: Kalkine Media
[A cancer cell is being targeted by immune cells: T cells, NK cells, macrophages. Cellular interaction, phagocytosis process, activation of a mast cell, histamine granules] quantic69/iStock via Getty Images Shares of Nurix Therapeutics (NASDAQ:NRIX [https://seekingalpha.com/symbol/NRIX]) fell on Thursday after the company updated data from a Phase 1a/b clinical trial for its lead asset bexobrutideg (NX-5948) in patients with relapsed or refractory B-cell malignancies. The data had been selected for a presentation at the ongoing European Hematology Association Congress. According to Nurix (NASDAQ:NRIX [https://seekingalpha.com/symbol/NRIX]), its Bruton’s tyrosine kinase degrader achieved an overall objective response rate of 80.9% among 47 patients with relapsed or refractory chronic lymphocytic leukemia. Citing data from 19 patients, the company added that those with Waldenström Macroglobulinemia witnessed an overall objective response rate of 84.2%.

The analysis was based on a data cut on March 12 when the median follow-up period had approached nine months. The study, designed to test oral bexobrutide doses ranging from 50 mg to 600 mg, indicated a well-tolerated safety profile for the drug with no safety signals, the company noted. Nurix (NASDAQ:NRIX [https://seekingalpha.com/symbol/NRIX]) reaffirmed its plans to begin pivotal trials for bexobrutideg this year. [https://seekingalpha.com/pr/20134575-nurix-therapeutics-presents-updated-positive-data-demonstrating-durable-deepening-responses] MORE ON NURIX * Nurix Therapeutics: IRAK4 GS-6971 Isn't Only Protein Degrader With Big Potential [https://seekingalpha.com/article/4776031-nurix-therapeutics-irak4-gs-6971-isnt-only-protein-degrader-with-big-potential] * Nurix Therapeutics: A Story To Monitor [https://seekingalpha.com/article/4759282-nurix-therapeutics-a-story-to-monitor] * Nurix Therapeutics: Speculative Bet On BTK Degraders And Targeted Protein Modulation [https://seekingalpha.com/article/4748505-nurix-therapeutics-speculative-bet-on-btk-degraders-and-targeted-protein-modulation] * Nurix gets FDA clearance to initiate trial for its anti-inflammatory drug candidate [https://seekingalpha.com/news/4432156-nurix-gets-fda-clearance-to-initiate-trial-for-its-anti-inflammatory-drug-candidate] * Nurix Therapeutics GAAP EPS of -$0.67 beats by $0.11, revenue of $18.45M beats by $5.42M [https://seekingalpha.com/news/4429579-nurix-therapeutics-gaap-eps-of-0_67-beats-by-0_11-revenue-of-18_45m-beats-by-5_42m]

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