Starpharma Holdings Limited’s (ASX: SPL) share price surged 3.387% to $1.282 after announcing that its proprietary DEP irinotecan development candidate showed complete tumour regression and 100% survival in a human pancreatic cancer model. This is compared with traditional irinotecan, Camptosar, alone and in combination with 5- fluorouracil.
In the study, human pancreatic tumour model did not respond to standard irinotecan regimen but Starpharma’s DEP irinotecan induced complete tumour regression and 100% survival.
The significant efficacy of DEP irinotecan defeats human pancreatic cancer which is a leading cause of death among oncologic diseases, with a one-year relative survival rate of 20%, and a five-year survival rate of only 7%. This result builds on efficacy data for DEP irinotecan in human colon cancer models, announced previously.
As per the release, DEP irinotecan is now expected to enter the clinic in FY19 which will be the entry of Starpharma’s third internal DEP candidate to clinical development. Moreover, the company is currently engaged in completing final development and manufacturing of finished product and other trial preparations for DEP irinotecan phase 1 / 2 trial.
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