Nitrogen and Phosphorus Balance Holds Key to Global Health and Disease Dynamics

October 19, 2023 07:53 PM AEDT | By EIN Presswire

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CHINA, October 19, 2023 /EINPresswire.com/ -- The delicate balance between nitrogen (N) and phosphorus (P) in our environment, known as the N:P ratio, has long been understood in the context of nature and food. But a new study suggests that this balance might have far-reaching impacts on our health, influencing everything from the rise of certain cancers to the spread of infectious diseases like malaria and Zika.

In a seminal study released on August 24, 2023, in the journal Eco-Environment & Health, the Global Ecology Unit CREAF‐CSIC‐UAB delved into the profound health implications of changing N:P ratios. This comprehensive analysis spanned across non-infectious to infectious diseases, unraveling their intricate ties to these nutrient imbalances and revealed the deep influence of global fertilizer disparities on human growth patterns.

Specifically, the observed differences in height among men in affluent countries appeared to be directly related to changes in their intake of nitrogen and phosphorus. Excessive use of nitrogen-based fertilizers increased the risk of diseases such as coeliac, mainly due to the presence of allergenic proteins like gluten. Alarmingly, young children under the age of five showed increased vulnerability to nitrates in their drinking water, which was a direct result of uncontrolled fertilizer use. Further investigation into the connection between phosphates and cancer revealed startling discoveries. Consuming higher levels of phosphates led to tumor growth in experimental animals. The imbalanced ratio of nitrogen to phosphorus resulting from elevated phosphate consumption was closely linked to an increased occurrence of cancer. This mounting presence of phosphate in food, a direct consequence of human activities, raises serious concerns about food safety.

However, amid these troubling findings, the study also provided a ray of hope. It proposed the promising idea of incorporating the stoichiometric theory into cancer treatments. By adjusting the ratios of nitrogen to phosphorus, it could potentially enhance the effectiveness of certain therapies, introducing a new strategy against this disease. Furthermore, the research shed light on infectious diseases, emphasizing the crucial role of environmental nutrient balance in the proliferation and transmission of pathogens. Malaria, for example, a disease that affects millions of people every year, stood out prominently in this context. Changes in N:P ratios could impact the habitats and reproductive rates of carriers like mosquitoes, consequently exacerbating the spread of the disease.

Essentially, this groundbreaking study emphasizes the urgent need to comprehend and tackle the complex consequences of nutrient imbalances on global health. By delving deeper into the intricacies of the N:P ratio, we can develop innovative strategies for managing fertilizers. By addressing these imbalances, we may equip ourselves with the means to combat prevalent diseases and foster a healthier global community.

Funding information
Grants TED 2021-132627B-I00 and PID2022-140808NB-I00 funded by MCIN, AEI/10.13039/501100011033 and by the European Union NextGenerationEU/PRTR,
grant CIVP20A6621 from the Fundación Ramón Areces. .

DOI: 10.1016/j.eehl.2023.08.003
Original URL: https://doi.org/10.1016/j.eehl.2023.08.003

Lucy Wang
BioDesign Research
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