Why is PYC Therapeutics (ASX:PYC) trading higher today?

Source: GoYong,Shutterstock


  • PYC Therapeutics’ investigational drug, VP-001, has restored function of the Retinal Pigment Epithelium.
  • This achievement differentiates PYC’s RNA approach from Adeno-Associated Virus.
  • PYC’s share price is trading 3.4 per cent up at A$0.15 (as at 11:06 AM AEDT).

On 2 March 2020, PYC Therapeutics (ASX: PYC) announced that it's lead investigational drug, VP-001, for the treatment of RP11 has restored the function of the Retinal Pigment Epithelium, the target cells for the therapy.

VP-001 has now demonstrated an ability to restore the integrity of the blood-retina barrier lost in patients with the disease in models derived from patients with RP11. The data provide the first evidence of restoration of the barrier function of the RPE monolayer and add to the previously released efficacy data for VP-001, demonstrating an ability to correct the functional deficits seen in individual RPE cells in patients with RP11.

In addition to the results supporting improved barrier function of the RPE monolayer, correction of the morphology (the ‘structure’ of the cell) has also been seen after treatment with VP-001. This quantifies the visual evidence of the improvement PYC demonstrated after treatment with VP-001.

Read More: PYC Therapeutics Successfully Completed Evaluation of CPP

Management Commentary

Sahm Nasseri, Chief Executive Office of PYC US, said, “Patients with RP11 are desperately waiting for a treatment option. These data shared today represent exciting progress for VP-001 as PYC strives to elucidate the potential of this breakthrough RNA agent as we advance towards the clinic.

Beyond these results, we look forward to sharing continued progress for VP-001 through our critical extensive animal studies in the middle of 2021, intending to submit an Investigational New Drug (IND) application to the USFDA during the first half of 2022.

Stock Performance

Image Source: Copyright © 2021 Kalkine Media Pty Ltd.

In the early trading session, PYC’s share price is trading 3.4 per cent up at A$0.15 (as at 11:06 AM AEDT). During the last six months, the stock has given a decent up move of around 25 per cent. The one-year return stands at an impressive 150 per cent.



The website https://kalkinemedia.com/au is a service of Kalkine Media Pty. Ltd. (Kalkine Media) A.C.N. 629 651 672. The principal purpose of the content on this website is to provide factual information only and does not contain or imply any recommendation or opinion intended to influence your financial decisions and must not be relied upon by you as such. Some of the content on this website may be sponsored/non-sponsored, as applicable, but is NOT a solicitation or recommendation to buy, sell or hold the stock of the company (or companies) or engage in any investment activity under discussion. We are neither licensed nor qualified to provide investment advice through this platform. In providing you with the content on this website, we have not considered your objectives, financial situation or needs. You should make your own enquiries and obtain your own independent advice prior to making any financial decisions.
Some of the images that may be used on this website are copyright to their respective owner(s). Kalkine Media does not claim ownership of any of the pictures displayed on this website unless stated otherwise. The images that may be used on this website are taken from various sources on the web and are believed to be in public domain. We have used reasonable efforts to accredit the source (public domain/CC0 status) to where it was found and indicated it below the image. The information provided on the website is in good faith, however Kalkine Media does not make any representation or warranty regarding the content, accuracy, or use of the content on the website.


We use cookies to ensure that we give you the best experience on our website. If you continue to use this site we will assume that you are happy with it. OK