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Chimeric Therapeutics bags an exclusive licence to novel CDH17 CAR T cell therapy

Summary

  • Chimeric Therapeutics has entered into an exclusive licence agreement with the University of Pennsylvania for the first CDH17 CAR T cell therapy.
  • As part of the agreement, Chimeric has acquired exclusive rights to develop and commercialise the CDH17 CAR T therapy.
  • CDH17 CAR T’s preclinical studies have demonstrated safety without any toxicity to normal tissues.
  • The development of this novel therapy is currently underway, with a Phase 1 trial scheduled to commence in 2022.

In a noteworthy development, Chimeric Therapeutics Limited (ASX:CHM) disclosed that it has entered into an exclusive licensing agreement with a world-renowned cell therapy centre, the University of Pennsylvania (Penn). As part of the agreement, Chimeric has received an exclusive licence to the CDH17 CAR T cell therapy.

The third generation CDH17 CAR T therapy targets CDH17, an oncogenic factor linked with poor prognosis and metastasis in neuroendocrine tumours as well as in the most common gastrointestinal tumours such as pancreatic,  colorectal, and gastric cancers.

MUST READ: Can Chimeric Therapeutics' CLTX CAR T therapy blaze a trail in GBM treatment?

CDH17 CAR T Cell Therapy

The CDH17 CAR T cell therapy is a next-generation CAR T cell therapy, which uses a novel technology to focus precisely on the challenges of solid tumours. CDH17 CAR T’s preclinical studies have demonstrated safety, ruling out any toxicity to normal tissues. The studies also depict the therapy’s efficacy with complete eradication of tumour cells and no relapse of the tumour.

Promising Preclinical Efficacy of CDH17 CAR T cell therapy, Source: CHM Website

DO WATCH: Expert Talks With Kalkine || Ms Jennifer Chow, Chief Operating Officer of Chimeric Therapeutics

Leading cellular immunotherapy scientist Xianxin Hua, MD, PhD, and his team, have been committed to the research and optimisation of the novel CDH17 CAR T cell therapy for over a decade.

Dr Hua is a professor of Cancer Biology in the Perelman School of Medicine of the University of Pennsylvania. He is also an investigator at the Abramson Family Cancer Research Institute and a Harrington Scholar Innovator.

Jennifer Chow, COO of Chimeric Therapeutics, stated-

Adding to this, Dr Hua commented-

CDH17 CAR T therapy development is underway, with a Phase 1 clinical trial planned to commence in 2022 at the University of Pennsylvania. In addition, a three-year commitment for further R&D has been made to Dr Hua and Penn.

The University of Pennsylvania is a global leader in cellular immunotherapy and is widely known for being home to the first FDA-approved CAR T therapy. The CHM team will leverage Penn’s unique cell therapy expertise to ensure the rapid development and commercialisation of the novel CDH17 CAR T cell therapy.

ALSO READ: Chimeric Therapeutics bringing innovation to the fore with its CLTX CAR T Therapy

Licence agreement details

Under the terms of the agreement, CHM has acquired the exclusive rights to develop and commercialise the CDH17 CAR T cell therapy. The Company has agreed to pay Penn licence fees, development milestones, and royalty payments based on commercial net sales. Besides, Chimeric also notified that the upfront fees associated with the licence agreement would be entirely funded from existing cash reserves.

Paul Hopper, Executive Chairman of Chimeric, commented-

On 29 July, Chimeric Therapeutics’ shares were trading at AU$0.325 (at 10:40 AM AEST).

DO READ: Another milestone as Chimeric Therapeutics’ (ASX:CHM) Phase 1 CLTX CAR T trial moves ahead

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